Drugs & Vitamins

Ibandronate Injection Active Ingredients: Ibandronate Injection What is ibandronate injection? What should I tell my health care provider before I take this medicine? How should this medicine be used? What if I miss a dose? What drug(s) may interact with ibandronate? What side effects may I notice from receiving Ibandronate? What should I watch for while taking Ibandronate? Where can I keep my medicine? What is ibandronate injection? (Back to top) IBANDRONATE (Boniva™) reduces calcium loss from bones. It helps prevent bone loss and increases production of normal healthy bone in patients with osteoporosis and other conditions which place someone at risk for bone loss, including after menopause in females. Generic ibandronate injection is not yet available. What should I tell my health care provider before I take this medicine? (Back to top) They need to know if you have any of these conditions: •dental disease •kidney disease •low level of blood calcium •problems swallowing •stomach, intestinal, or esophageal problems, like acid-reflux or GERD •vitamin D deficiency •an unusual or allergic reaction to ibandronate, other medicines, foods, dyes, or preservatives •pregnant or trying to get pregnant •breast-feeding How should this medicine be used? (Back to top) Ibandronate is for injection into a vein. It is given by a health care professional, usually in a hospital or clinic setting. Contact your pediatrician or health care professional regarding the use of this medicine in children. Special care may be needed. What if I miss a dose? (Back to top) This does not apply. What drug(s) may interact with ibandronate? (Back to top) •aluminum hydroxide •antacids •anti-inflammatory drugs like ibuprofen, naproxen, and others •aspirin •calcium supplements •certain antibiotics given by injection •certain water pills or diuretics (examples include Bumex®, Demadex®, Lasix®, or furosemide) •cyclosporine •iron supplements •magnesium supplements •parathyroid hormone •teriparatide •vitamins with minerals Tell your prescriber or health care professional about all other medicines you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines. What side effects may I notice from receiving Ibandronate? (Back to top) Side effects that you should report to your prescriber or health care professional as soon as possible: •black or tarry stools •constant jaw pain, especially burning or cramping •eye inflammation, pain or change in vision •pain or difficulty passing urine •skin rash, itching (hives) •swelling of the lips, arms, legs, face, tongue, or throat •vomiting •allergic reactions such as hives, swelling of the face, lips or tongue Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome): •diarrhea or constipation •fever •headache •nausea •bone, muscle or joint pain •rash •redness, pain, swelling, or irritation at the injection site What should I watch for while taking Ibandronate? (Back to top) Visit your prescriber or health care professional for regular checks on your progress. Low blood levels of phosphorus and calcium can occur but usually do not cause serious problems. Your prescriber or health care professional may order regular blood tests to check for these problems. You should make sure you get enough calcium and vitamin D in your diet while you are taking ibandronate, unless directed otherwise by your health care provider. Discuss your dietary needs with your health care professional or nutritionist. If you get bone pain, or a worsening of bone pain, check with your doctor. However, many patients have improvement in their bone pain during and after treatment with ibandronate. Where can I keep my medicine? (Back to top) This medication is only given in a hospital or clinic. You will not keep this medicine at home. Last Updated:01/13/2006 CLINICAL PHARMACOLOGY© GOLD STANDARD MULTIMEDIA INC, ALL RIGHTS RESERVED

Note: The above information is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist, or other healthcare professional. It should not be construed to indicate that the use of the product is safe, appropriate, or effective for you. Consult your healthcare professional before taking the product.